Trisomy 21 mongolism and D/D translocation occurred in the same individual. To our knowledge, this is the second case of this phenomenon. Three additional members of this patient's family were found to be D/D translocation carriers. Four additional instances in which these two abnormalities are associated within a single family are found in the literature. It is suggested that this association may well be significant and is worthy of further study.
Brown RK, Burdick CO, Malone HJ, Wright YM. Familial D/D Translocation Associated With Trisomy 21: Report of a Case With Pedigree Study. JAMA. 1967;202(1):60–62. doi:10.1001/jama.1967.03130140118027
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