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October 2, 1967

Familial D/D Translocation Associated With Trisomy 21: Report of a Case With Pedigree Study

Author Affiliations

From the Department of Pathology, 406th Medical Laboratory, US Army Medical Command, Japan (Drs. Brown and Burdick), Department of Pediatrics, Manchester (Conn) Memorial Hospital (Dr. Malone), and Hartford (Conn) Hospital (Miss Wright).

JAMA. 1967;202(1):60-62. doi:10.1001/jama.1967.03130140118027

Trisomy 21 mongolism and D/D translocation occurred in the same individual. To our knowledge, this is the second case of this phenomenon. Three additional members of this patient's family were found to be D/D translocation carriers. Four additional instances in which these two abnormalities are associated within a single family are found in the literature. It is suggested that this association may well be significant and is worthy of further study.