Intermittent peritoneal dialysis was performed to observe the effect of dialysate temperature and flow rate on peritoneal clearance. At the same hourly flow rates, the dialysate heated to 37 C had a 35% greater clearance than the dialysate at 20 C. The most efficient method of dialysis with commercially available equipment is a repeated 2-liter exchange of dialysate at 37 C with no pause between inflow and outflow. This method in an average dialysate volume of 3.3 liters/hr and an average urea nitrogen clearance of 20.8 ml/min.
Gross M, McDonald HP. Effect of Dialysate Temperature and Flow Rate on Peritoneal Clearance. JAMA. 1967;202(4):363–365. doi:10.1001/jama.1967.03130170163035
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