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November 6, 1967

Studies of Venereal Disease: I. Probenecid-Procaine Penicillin G Combination and Tetracycline Hydrochloride in the Treatment of "Penicillin-Resistant" Gonorrhea in Men

Author Affiliations

From US Navy Preventive Medicine Unit No. 6, Pearl Harbor, and the Department of Microbiology, University of Hawaii, Honolulu. CAPT Floyd is now with Navy Preventive Medicine Unit No. 5, San Diego, Calif; LCDR Johnson with Navy Medical Research Unit No. 1, Berkeley, Calif; and LT Holmes with the Department of Internal Medicine, University of Washington Hospital, Seattle.

JAMA. 1967;202(6):461-466. doi:10.1001/jama.1967.03130190067008

Treatment of gonorrhea in men with a single intramuscular dose of 2,400,000 units of procaine penicillin G, recommended by the US Public Health Service and the armed forces in 1965, continues to result in 20% to 30% treatment failures among military personnel in the Far East. In studies of confined populations aboard air-craft carriers, 63 men with gonorrhea received 2,400,000 units of procaine penicillin G with 18 (29%) treatment failures; 58 men received 2,400,000 units procaine penicillin G plus probenecid orally, with only one failure. Resistance to 0.06 units of penicillin per milliliter of medium was noted in 26 of 41 (63%) and 57 of 74 (77%) Neisseria gonorrhoeae isolates from the respective groups. Thirty men received tetracycline hydrochloride orally, with no failures. In areas where treatment of gonorrhea with large parenteral doses of penicillin G is becoming less effective, adequate therapy is possible with probenecid plus penicillin or with tetracycline.