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November 6, 1967

Studies of Venereal Disease: III. Double-Blind Comparison of Tetracycline Hydrochloride and Placebo in Treatment of Nongonococcal Urethritis

Author Affiliations

From US Navy Preventive Medicine Unit No. 6, Pearl Harbor, and the Department of Microbiology, University of Hawaii, Honolulu. CAPT Floyd is now with Navy Preventive Medicine Unit No. 5, San Diego, Calif; LCDR Johnson with Navy Medical Research Unit No. 1, Berkeley, Calif; and LT Holmes with the Department of Internal Medicine, University of Washington Hospital, Seattle.

JAMA. 1967;202(6):474-476. doi:10.1001/jama.1967.03130190080010

Previous studies of the treatment of nongonococcal urethritis (NGU) have generally not been closely controlled, and have often produced conflicting results. In the present study, 96 men with NGU were treated with placebo or tetracycline hydrochloride while "confined" aboard an aircraft carrier at sea. A seven-day tetracycline regimen was more effective than a four-day tetracycline regimen or placebo in the short-term cure of NGU.