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November 6, 1967

Rhinovirus Infections in an Industrial Population: II. Characteristics of Illness and Antibody Response

Author Affiliations

From the departments of preventive medicine, internal medicine (Drs. Gwaltney and Jordan), and pediatrics (Drs. Hendley and Simon), University of Virginia School of Medicine, Charlottesville; and the Communicable Disease Center, US Public Health Service (Drs. Simon and Hendley). Dr. Simon is now with Babies Hospital, Columbia-Presbyterian Hospital, New York.

JAMA. 1967;202(6):494-500. doi:10.1001/jama.1967.03130190100014

Rhinovirus illness in young adults was characterized by rhinorrhea, nasal obstruction, sneezing, and pharyngeal discomfort. Length of illness ranged from 1 to 33 days, with a median of 7.42 days; one fourth of the illnesses lasted two weeks. Nasal symptoms, hoarseness, and cough occurred more frequently with confirmed rhinovirus common colds than with illnesses from which rhinoviruses were not cultured. Significant neutralizing antibody responses were measured in 77% of 77 paired serum specimens from patients with rhinovirus illness; only 5% had homologous titers of 8 or more in the acute phase of illness. The findings support other data indicating that serum neutralizing antibody develops following the majority of rhinovirus illnesses and is important in preventing symptomatic rhinovirus infection.