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April 21, 1975

Vitamins C and B12

Author Affiliations

Veterans Administration Hospital St. Louis University Group Hospitals St. Louis

JAMA. 1975;232(3):246. doi:10.1001/jama.1975.03250030010002

To the Editor.—  The spinal cord injury service at our hospital brings us in contact with a large number of patients at high risk for urinary tract infections. Thus, we read with great interest the recent article by Herbert and Jacob (230:241, 1974) regarding the in vitro destruction of vitamin B12 by ascorbic acid.As a routine procedure, all of the spinal cord injury patients on our service receive doses of ascorbic acid of or more than 4 gm/day to enhance urinary acidity. We measured serum vitamin B12 levels by the technique of radioisotope displacement in ten male patients, aged 17 to 69 years. Each of these patients had received ascorbic acid in this dose for more than 11 months. All had been on unrestricted diets and all took their medication in four divided doses each day. The vitamin B12 levels were all well above the low

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