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November 6, 1967

Persistent Tachycardia, Paroxysmal Hypertension, and Seizures: Association With Hyperglycinuria, Dominantly Inherited Microphthalmia, and Cataracts

Author Affiliations

From the Department of Medicine, Vanderbilt University Medical School, Nashville, Tenn.

JAMA. 1967;202(6):525-530. doi:10.1001/jama.1967.03130190131020

A 35-year-old woman underwent diagnostic studies because of an 18-year history of paroxysmal tachycardia, hypertension, syncope, and seizures. The studies and postmortem examination failed to reveal any recognized cause for the cardiac symptoms. Associated findings included dominantly inherited microphthalmia with cataracts, and hyperglycinuria with renal stones. The findings appear to constitute an unusual genetically determined syndrome resulting from a still uncharacterized abnormality in glycine metabolism.