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June 2, 1975

Erythroplasia of Queyrat: Treatment With Topically Applied Fluorouracil

Author Affiliations

From the departments of dermatology, Walter Reed General Hospital (LTC Goette), the George Washington University School of Medicine (Dr. Elgart), Washington, DC, and the Brooke Army Medical Center, Fort Sam Houston, Tex (MAJ DeVillez). Dr. Goette is now at the Letterman Army Medical Center, San Francisco.

JAMA. 1975;232(9):934-937. doi:10.1001/jama.1975.03250090024012

Three patients with biopsy-confirmed erythroplasia of Queyrat were treated with topically applied fluorouracil. The lesions cleared completely, and recurrence-free follow-up periods ranged from 20 to 60 months. There were normal histological findings in posttreatment biopsy specimens in two of the patients.

A literature review yielded five additional cases successfully treated with fluorouracil applied topically. Patients with histologically confirmed erythroplasia of Queyrat should be afforded treatment with topically applied fluorouracil, as results appear to be superior to those of surgical or radiological treatment, with less morbidity.

(JAMA 232:934-937, 1975)

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