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December 11, 1967

Hyperosmolar Anacidotic Coma in Association With Glucocorticoid Therapy

Author Affiliations

From the Department of Medicine, University Hospitals of Cleveland. Dr. Boyer is now with Nuffield Department of Clinical Medicine, the Radcliffe Infirmary, Oxford, England.

JAMA. 1967;202(11):1007-1009. doi:10.1001/jama.1967.03130240049007

The syndrome of marked hyperglycemia, coma, and death not associated with keto acidosis has received increasing recognition. Hyperosmolarity of the serum and severe dehydration are important features of this disorder. This report of three patients, two of whom survived, emphasizes the role of prior glucocorticoid therapy in precipitating the syndrome.