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December 25, 1967


JAMA. 1967;202(13):23-33. doi:10.1001/jama.1967.03130260011003

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Chromosomal Imbalance Found; May Relate To Malignant Behavior  Among the many diverse chromosomal abnormalities that exist in human cancer cells, a specific, consistent abnormality has been found which may be associated with malignant behavior.This invariant abnormality is an excess of E16 chromosomes, either absolute or relative to certain other classes of chromosomes, John W. Gofman, MD, PhD, told a symposium in Oklahoma City.Dr. Gofman is professor of medical physics and associate director of the University of California's Lawrence Radiation Laboratory at Livermore.Seven established human malignant cell lines and two human cancers have been studied by the computerized chromosome scanning techniques worked out at the Lawrence laboratory; the results although consistent, will need to be confirmed and verified in other cancers before any definite conclusions can be reached.Nevertheless, the consistency with which this abnormality has been found prompted Dr. Gofman to comment:"This invariant (E16 excess)