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January 1, 1968

Jeryl Lynn Strain Live Attenuated Mumps Virus Vaccine: Influence of Age, Virus Dose, Lot, and γGlobulin Administration on Response

Author Affiliations

From the Division of Virus and Cell Biology Research, Merck Institute for Therapeutic Research, West Point, Pa (Drs. Buynak. Hilleman, Leagus, and Whitman), and the Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia (Drs. Weibel and Stokes).

JAMA. 1968;203(1):9-13. doi:10.1001/jama.1968.03140010011002

The influence of age, virus dose, lot, and γ-globulin administration on serologic and clinical responses to Jeryl Lynn strain live attenuated mumps virus vaccine was studied. Fever or other clinical reaction referable to the vaccine did not develop in childen given vaccine subcutaneously or by jet gun. Mumps antibody of maternal origin suppressed the serologic response to the vaccine. Replicate lots of vaccine gave equally acceptable performance in children. Three hundred seventeen tissue culture doses of mumps vaccine virus were sufficient to immunize. Up to 100 units of mumps neutralizing antibody in human immune globulin coadministered with vaccine but given into the opposite arm did not suppress serologic response to the vaccine. The vaccine was stable for at least one year in dried form and for at least eight hours at 4 C following rehydration.