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January 1, 1968

Anaphylactic Reaction To γ-globulin

Author Affiliations

Pleasantville, NY

JAMA. 1968;203(1):59. doi:10.1001/jama.1968.03140010061029

To the Editor:—  A 7-year-old white boy has been under my care for approximately 4 1/2 years, because of repeated upper-respiratory tract infections, and episodes of tonsilitis, somewhat helped by tonsillectomy at the age of 4. Additional complications have been nonspecific croup, bronchopneumonia, and superficial skin abscesses. Frequent and severe otitis media has usually been a consequence of an upper-respiratory tract infection. The boy would complain of pain in one ear in the morning, and, despite immediate administration of decongestants and antibiotics, perforation of the ear drum would take place in six to seven hours. This happened four or five times in four years, in addition to attacks of otitis media without perforation at least once a month.Otologic and other studies have reported only perennial nasopharyngitis of infectious origin. Cultures of nasopharyngeal and ear exudates have yielded Haemophilus influenzae, Staphylococcus aureus, coagulase positive, pneumococci, and streptococci of the viridans