During a ten-year period (1956-1966), fifty-six patients underwent surgical hypophysectomy for the treatment of progressive diabetic retinopathy. Of 47 patients who had adequate follow-up study for evaluation of the effects on the course of the retinopathy, 37 (78.7%) were benefited. After the early experience with hypophysectomy in 18 unselected patients resulting in four postoperative deaths, a more rigid selection on the basis of age and cardiovascular and renal function resulted in avoiding postoperative mortality in the next 38 patients. Hypophysectomy appears to be a desirable method of treatment in the carefully selected diabetic patient who is threatened with blindness.
Ray BS, Pazianos AG, Greenberg E, Peretz WL, McLean JM. Pituitary Ablation for Diabetic Retinopathy: I. Results of Hypophysectomy (A Ten-Year Evaluation). JAMA. 1968;203(2):79–84. doi:10.1001/jama.1968.03140020007002
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