Pregnancy in a patient with a prosthetic mitral valve was carried to term without any overt evidence of medical complications. The infant was born with hypoplastic nasal structures. Warfarin (Coumadin) sodium is suspected as the teratogenic agent.
Kerber IJ, Warr OS, Richardson C. Pregnancy in a Patient With a Prosthetic Mitral Valve: Associated With a Fetal Anomaly Attributed to Warfarin Sodium. JAMA. 1968;203(3):223–225. doi:10.1001/jama.1968.03140030055015
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