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January 15, 1968

Pregnancy in a Patient With a Prosthetic Mitral Valve: Associated With a Fetal Anomaly Attributed to Warfarin Sodium

Author Affiliations

From the departments of obstetrics and gynecology and medicine, University of Tennessee College of Medicine, and the City of Memphis Hospitals, Memphis.

JAMA. 1968;203(3):223-225. doi:10.1001/jama.1968.03140030055015

Pregnancy in a patient with a prosthetic mitral valve was carried to term without any overt evidence of medical complications. The infant was born with hypoplastic nasal structures. Warfarin (Coumadin) sodium is suspected as the teratogenic agent.