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January 29, 1968

Progestogen-Induced Adenomatous Hyperplasia of the Uterine Cervix

Author Affiliations

From the Department of Pathology, University of Michigan, Ann Arbor. Dr. Candy was an Elsa U. Pardee student cancer fellow, Department of Pathology, University of Michigan, and is now at the US Naval Hospital, Oakland, Calif.

JAMA. 1968;203(5):323-326. doi:10.1001/jama.1968.03140050007002

A distinctive adenomatous and cribriform hyperplasia of gland and reserve cells of the uterine cervix is attributed to progestogens. The lesions were polypoid or verrucose and located near the squamocolumnar junction. Carcinoma was usually suspected on clinical examination, and on biopsy the diagnosis of adenocarcinoma was either made or seriously entertained for seven of 12 patients. The natural history of the lesion does not indicate any likelihood of progression to carcinoma.