[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
January 29, 1968

Hypercalcemia in Cutaneous Lymphosarcoma With Response to Methotrexate

Author Affiliations

From the Department of Internal Medicine, Lahey Clinic Foundation, Boston.

JAMA. 1968;203(5):359-362. doi:10.1001/jama.1968.03140050043014

In a case of cutaneous lymphosarcoma and symptomatic hypercalcemia, there was no radiographic evidence of skeletal involvement. Both the hypercalcemia and the tumor growth were controlled by the use of continuous intravenously administered methotrexate. This antimetabolite is effective in the treatment of lymphosarcoma associated with hypercalcemia, and it may be useful in evaluating the mechanism of hypercalcemia associated with malignancy.