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February 12, 1968


JAMA. 1968;203(7):25-38. doi:10.1001/jama.1968.03140070101051

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Clinical Stimulation Of Interferon 

Predicted This Year; Research Intensifies  Cautious clinical attempts to trigger significant interferon production in man may begin in 1968.These human experiments, using a double-stranded ribonucleic acid (RNA), now appear feasible, two investigators agree. They will come some 11 years after the naturallyoccurring anti-viral substance was first reported by English investigators."In months rather than weeks, but certainly within a year, we will be prepared for clinical evaluation," predicted Maurice R. Hilleman, PhD, DSc."Over recent months, results from several laboratories have caused interferon work to spiral upward rapidly," said Samuel Baron, MD. "The momentum is definitely toward human trial."Speaking at separate meetings in New York and Philadelphia, both men cautioned that unexpected hurdles may remain. Dr. Baron, of the National Institute of Allergy and Infectious Diseases, spoke before the American Chemical Society's mid-Atlantic meeting. Dr. Hilleman, who reviewed the field at the