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February 19, 1968

Thrombocytopenia Caused by Cephalothin Sodium: Occurrence in a Penicillin-Sensitive Individual

Author Affiliations

From the Department of Medicine and Laboratories, Bronx-Lebanon (NY) Hospital Center.

JAMA. 1968;203(8):601-603. doi:10.1001/jama.1968.03140080061020

Thrombocytopenia due to use of cephalothin sodium developed in an individual with a history of sensitivity to penicillin and no prior exposure to cephalothin. The in vitro studies bore out the clinical impression of cephalothin-induced thrombocytopenia, although hemagglutinating techniques failed to demonstrate erythrocyte-related antibodies to either penicillin or cephalothin. There is a possible but not proved relationship between penicillin sensitivity and cephalothin sensitivity. Patients receiving cephalothin should be observed carefully for blood dyscrasia.