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Article
February 26, 1968

Gastric Mucosal Mast Cells in the Common Laboratory Animals and Man

Author Affiliations

From the Gastrointestinal Research Unit of the Department of Surgery, Albert Einstein College of Medicine, New York.

JAMA. 1968;203(9):654-656. doi:10.1001/jama.1968.03140090038010
Abstract

The mast-cell content of the gastric corpus and antrum mucosa of the frog, mouse, rat, hamster, guinea pig, rabbit, cat, dog, and man was studied with an improved method which increases the specificity of the toluidine blue stain for mast cells. Great variability in the density and distribution of gastric mucosal mast cells was noted in the different species. There appears to be no relationship between the known sensitivity of the stomach of a given species to histamine stimulation and its mast-cell content. None of the species demonstrated a topographic association between mucosal mast cells and parietal cells. The notion that endogenous histamine released from mucosal mast cells ultimately causes acid secretion cannot be supported by our data. It is more likely that non-mast-cell histamine is the physiologically active agent.

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