Coproantibodies to the peptic-tryptic digest of wheat (fraction III) were demonstrated in three patients with celiac disease but were not demonstrated in 14 control subjects with various diarrheal diseases nor in six normal subjects. This preliminary report suggests that the polypeptides of gluten may elicit the production of antibodies within the gut and that the intestine continues to secrete these antibodies for extended periods even in the apparent absence of ingested wheat proteins. These copro-antibody studies are being further evaluated as to their specificity in the diagnosis of celiac disease.
Teodoro Herskovic, Julian Katz, Joyce D. Gryboski, Howard M. Spiro. Coproantibodies to Gluten in Celiac Disease. JAMA. 1968;203(10):887–888. doi:10.1001/jama.1968.03140100069021