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March 11, 1968

Kanamycin Sulfate in the Treatment of Acute Gonorrheal Urethritis in Men

Author Affiliations

From the divisions of adult health (Drs. Fischnaller and Pedersen) and laboratories (Mr. Bonin and Miss Tronca), Seattle-King County Health Department. Dr. Ronald is a fellow in the Department of Microbiology, University of Washington Medical School. Seattle.

JAMA. 1968;203(11):909-912. doi:10.1001/jama.1968.03140110001001

A single parenterally administered dose of 2 gm of kanamycin sulfate cured 144 (93%) of 155 men with acute gonorrheal urethritis. No untoward side effects of the drug were encountered. In vitro sensitivity was determined for 67 isolates, for penicillin, kanamycin, streptomycin, and tetracycline, and an increase in resistance to penicillin and tetracycline is shown over the preceding 16 to 18 months for the Seattle-King County area. The authors consider culture of the sediment of a centrifuged, freshlyvoided urine specimen to be the most reliable criterion of cure. Prolonged observation of the results of treatment is unreliable because of the likelihood of reinfection. There is a great need for additional parenterally administered drugs effective in treating gonorrhea. Concurrent treatment of consorts is of critical importance in avoiding reinfection.