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April 15, 1968

Chromosomal Damage in LSD Users

Author Affiliations

From the departments of Genetics (Dr. Egozcue) and psychopharmacology (Dr. Irwin), Oregon Regional Primate Research Center, Beaverton (Dr. Egozcue); the Departments of Psychiatry, University of Oregon Medical School, Portland (Dr. Irwin); and Departamento de Patologia, Hospital Juan A. Fernandez, Buenos Aires (Dr. Maruffo).

JAMA. 1968;204(3):214-218. doi:10.1001/jama.1968.03140160024006

An increase of chromosomal abnormalities was found in leukocytes of LSD users compared to drug-free controls. Elevated breakage rates were also found in children exposed to the drug in utero. The data showed no correlation between amount of drug per dose, number of doses, or total dosage and frequency of chromosomal breaks.

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