[Skip to Content]
[Skip to Content Landing]
September 6, 1971

Methadone Overdose: Illicit Use of Pharmaceutically Prepared Parenteral Narcotics

Author Affiliations

From the Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia.

JAMA. 1971;217(10):1387-1389. doi:10.1001/jama.1971.03190100069019

Two cases of overdose occurred with illicit use of methadone hydrochloride, intravenously injected. Pulmonary edema, myoglobinuria, and acute renal failure were prominent in these patients. They had injected themselves with pure methadone, which suggests that the overdose syndrome is caused by the narcotic itself and not by toxic diluents.