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Article
September 6, 1971

Tetracycline Treatment of Telangiectasia

Author Affiliations

Los Angeles

JAMA. 1971;217(10):1392. doi:10.1001/jama.1971.03190100074025

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Abstract

To the Editor.—  I was intrigued by the recent case report by Shelley, "Essential Progressive Telangiectasia: Successful Treatment with Tetracycline" (216:1343, 1971)—of a patient with this rare entity whose lesions cleared completely within a period of three months following the administration of tetracycline hydrochloride orally in a dose of 250 mg four times a day. In this 39-year-old woman, repeated general physical examinations had been noncontributory. The eruption, consisting of confluent areas of erythema and dilated capillaries, had begun on the tops and sides of the feet seven years previously and had gradually extended onto the ankles, legs, and thighs. Shelley was unable to explain the mechanism of action of tetracycline in this condition, feeling that it might have been on the basis of some little-understood pharmacodynamic action rather than the usual wide-spectrum antibiotic effect, although he speculated that a change in bowel flora must also be considered as

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