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May 6, 1968

Management of Persistently Recurring Ventricular Fibrillation With Propranolol Hydrochloride

Author Affiliations

From the Newark (NJ) Beth Israel Hospital Institute.

JAMA. 1968;204(6):546-548. doi:10.1001/jama.1968.03140190128017

Propranolol hydrochloride suppressed persistently recurring ventricular fibrillation in a patient with acute myocardial infarction after lidocaine, procainamide hydrochloride, and multiple electric shocks had failed. Propranolol must be used with care in the presence of acute myocardial infarction because of its negative inotropic and chronotropic effects. Propranolol should be administered by slow intravenous infusion if procainamide and lidocaine fail to suppress ventricular fibrillation. Rate of flow must be carefully monitored to avoid bradycardia, hypotension, and cardiac failure.