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Article
October 11, 1971

Medical News

JAMA. 1971;218(2):169-180. doi:10.1001/jama.1971.03190150005003

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Abstract

Are anti-N antibodies involved in kidney rejection  ?The cause of the failure of some kidney transplants may well be anti-N red cell antibodies, three San Francisco investigators say.The presence of auto-anti-N antibodies is significant in renal transplantation, Herbert A. Perkins, MD, and Eleanor D. Howell, BB (ASCP), reported, "if the donor kidney has been chilled to a temperature at which the antibody can agglutinate the patient's red cells."They told an American Association of Blood Banks annual meeting audience in Chicago: "We have seen two instances in which a type N patient with anti-N has obstructed a graft with agglutinated red cells, leading to failure. In each instance, a second kidney from the same cadaver donor functioned well after being infused with warm saline before implantation."Dr. Perkins, director of research for Irwin Memorial Blood Bank of the San Francisco Medical Society, and Mrs. Howell, supervising research technologist there,

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