A causal relationship of streptococci to glomerulonephritis was suggested as early as the beginning of this century.1 In the following 30 years the painstaking clinical and laboratory work of many investigators yielded evidence that glomerulonephritis is a sequela of infection with group A streptococci. From analysis of differences, chiefly epidemiologic, between glomerulonephritis and rheumatic fever, Seegal and Earle2 and Rammelkamp and associated3 concluded that only certain strains of group A streptococci have "nephritogenic" capacity. Considerable support for this view has come from subsequent epidemiologic and clinical observations.
How streptococci induce glomerulonephritis has not been determined. Do certain streptococci produce a principle injurious to renal tissue? Is glomerulonephritis a manifestation of allergy, as first suggested by von Pirquet4 in analogy with serum sickness? For gaining knowledge of these and other questions concerning the nature of glomerulonephritis, it has long been considered likely that the experimental induction of
EXPERIMENTAL INDUCTION OF GLOMERULONEPHRITIS WITH GROUP A STREPTOCOCCI. JAMA. 1968;204(10):922–923. doi:10.1001/jama.1968.03140230080014
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