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July 1, 1968

Metabolic and Hypotensive Effects of Ethacrynic Acid: Comparative Study With Hydrochlorothiazide

Author Affiliations

From the Department of Medicine and Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, and the Department of Medicine and the Gerontology Research Center, National Institute of Child Health and Human Development, Baltimore City Hospitals, Baltimore. Dr. Lindeman is now at the University of Oklahoma, Oklahoma City, and Dr. Prescott is now at the University of Aberdeen, Scotland.

JAMA. 1968;205(1):11-15. doi:10.1001/jama.1968.03140270035006

Twenty-four hypertensive outpatients were randomly allocated and received three successive six-week treatments: placebo, hydrochlorothiazide (200 mg daily), and ethacrynic acid (200 mg daily). Significantly diminished carbohydrate tolerances were observed when tests were conducted after hydrochlorothiazide therapy compared to results of tests conducted after administration of the placebo. Impaired carbohydrate tolerances observed when therapy with ethacrynic acid was compared with the use of placebo were most apparent in subjects with diabetes mellitus. Hydrochlorothiazide and ethacrynic acid effected responses of similar magnitude: pulse rate and serum concentrations of urea nitrogen and uric acid increased; body weight, recumbent and standing blood pressure, and serum concentrations of potassium and chloride decreased.