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August 12, 1968

Pathology of Leukemia

Author Affiliations

Bethesda, Md

JAMA. 1968;205(7):538. doi:10.1001/jama.1968.03140330080028

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Kudos! Kudos! For the first time in over a decade appears a book completely devoted to the pathophysiology of leukemia. The author, with the able assistance of four contributors, has utilized the large and personally supervised volume of biopsied and autopsied material from the City of Hope Medical Center. The book has five divisions covering classification, diagnosis and differential diagnosis, systemic organ alterations, physiopathologic changes, and infections. Photomicrographs are of unusually good quality. Each chapter contains extensive references, current through 1966.

The section on classification is handled well. In particular, I would agree with the statement regarding low number of true monocytic (histiocytic) leukemias. An unfortunate omission in the technical procedures is the failure to discuss the increasing importance of closed bone marrow biopsies. An excellent chapter on the ultrastructure of leukemic cells is marred only by the inclusion of a discussion of Auer bodies under normal myeloblasts. There is