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August 19, 1968

Fever as a Manifestation of Hypoglycemia

Author Affiliations

From the Joslin Clinic and the New England Deaconess Hospital. Dr. Ramos is now a fellow in diabetes of the Joslin Clinic and the Diabetes Foundation, Inc. Dr. Zorilla is a fellow in endocrinology of the New York University Hospital, New York.

JAMA. 1968;205(8):590-592. doi:10.1001/jama.1968.03140340060019

Fever associated with severe hypoglycemia was observed on 16 occasions in 14 patients. In most instances treatment with glucose failed to bring about prompt recovery of consciousness. Evidence suggests that both fever and delay in response to treatment are related to the presence of cerebral edema which may respond to treatment when appropriate measures, such as intravenous administration of mannitol are taken.