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January 3, 1972

Nonanoxic Aerosol Arrhythmias

Author Affiliations

From the Section of Cardiology, Medical Service, Forest Hills Division, Veterans Administration Hospital, and the Department of Medicine, Medical College of Georgia, Augusta.

JAMA. 1972;219(1):33-37. doi:10.1001/jama.1972.03190270013003

Cardiac arrhythmias were produced in dogs which were allowed to breathe aerosols propelled with fluorinated hydrocarbons. In spite of mixing with room air in ten animals, and careful maintenance of normal arterial oxygen tension, carbon dioxide tension, pH, base excess, and serum carbon dioxide level in six animals, the same general pattern of rhythm disturbances prevailed. These consisted mainly of slowing of the rate of the sinoatrial pacemaker with resultant junctional or ventricular escape rhythm and ultimate electrical asystole or ventricular fibrillation in eight animals, in spite of the fact that exposure to the agents was stopped at the earliest sign of rhythm change.