Cardiac arrhythmias were produced in dogs which were allowed to breathe aerosols propelled with fluorinated hydrocarbons. In spite of mixing with room air in ten animals, and careful maintenance of normal arterial oxygen tension, carbon dioxide tension, pH, base excess, and serum carbon dioxide level in six animals, the same general pattern of rhythm disturbances prevailed. These consisted mainly of slowing of the rate of the sinoatrial pacemaker with resultant junctional or ventricular escape rhythm and ultimate electrical asystole or ventricular fibrillation in eight animals, in spite of the fact that exposure to the agents was stopped at the earliest sign of rhythm change.
Flowers NC, Horan LG. Nonanoxic Aerosol Arrhythmias. JAMA. 1972;219(1):33–37. doi:10.1001/jama.1972.03190270013003
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: