In Alaska, acute suppurative otitis media has been reported as the second most frequent cause of morbidity in Aleut, Indian, and Eskimo children. A one-year double-blind prospective trial of ampicillin anhydrous taken orally as a prophylactic by 364 Eskimo children under the age of 7, residing in six villages in western Alaska, showed a 47% reduction in the incidence of otitis media. However, for children who took their medication well, the reduction in incidence was 67%.
Maynard JE, Fleshman JK, Tschopp CF. Otitis Media in Alaskan Eskimo ChildrenProspective Evaluation of Chemoprophylaxis. JAMA. 1972;219(5):597–599. doi:10.1001/jama.1972.03190310029006
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