Four patients had evidence of acute pancreatitis occurring during infectious hepatitis. Paper electrophoresis of serum and urine of one patient revealed migration patterns of amylolytic activity identical to those of saline extracts of human pancreas. Definite gross and histologic pancreatitis was seen at autopsy in two patients who died of acute fulminant hepatitis. The fourth patient had only mild increases in the level of urine amylase but a classical "reversed 3 sign" on roentgenograms of the uppergastrointestinal tract, that largely disappeared in eight days.
Achord JL. Acute Pancreatitis With Infectious Hepatitis. JAMA. 1968;205(12):837–840. doi:10.1001/jama.1968.03140380041008
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