[Skip to Content]
[Skip to Content Landing]
October 21, 1968


JAMA. 1968;206(4):749-764. doi:10.1001/jama.1968.03150040007003

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Is Manic Depression Hereditary  ?"A striking linkage" between the color blindness gene locus and manic depressive illness has been found by investigators from Washington University School of Medicine, St. Louis."We now have extremely Suggestive evidence of a genetic factor in manic depressive disease," said Eli Robins, MD, Wallace Renard Professor of Psychiatry and head of the Department of Psychiatry. Dr. Robins directs approximately 15 projects concerned with mania and depression, supported by the National Institute of Mental Health."Although it is quite likely that manic depressive illness and color blindness are linked on the same chromosome," said Dr. Robins, "our study does not mean that a person with color blindness is predisposed to manic depressive illness."The effort to pinpoint the genetic locus of affective disorders is part of a larger study to determine nature and mode of transmission of affective disorders. The work was conducted by George Winokur,