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October 21, 1968

Treatment of Candida Sepsis and Cryptococcus Meningitis With 5-Fluorocytosine: A New Antifungal Agent

Author Affiliations

From the departments of medicine, Choate Memorial Hospital, Woburn, Mass (Dr. Tassel), and Tufts University School of Medicine, and the Medical Services of the Lemuel Shattuck Hospital, Massachusetts Department of Public Health, Boston (Dr. Madoff).

JAMA. 1968;206(4):830-832. doi:10.1001/jama.1968.03150040042009

The two patients whom we treated for systemic fungus infections with 5-fluorocytosine, an antifungal agent effective in experimental animal infection with Candida and cryptococci, had a satisfactory clinical response in association with therapy. One patient with Candida sepsis received 5-fluorocytosine for 21 days in a dose ranging from 2 to 4 gm daily. The other patient, with cryptococcal meningitis recurring after amphotericin B treatment, received 5-fluorocytosine in a dose of 2.25 to 9 gm daily for 50 days. There was little evidence of drug toxicity. The new agent deserves controlled clinical evaluation in systemic fungus infections.

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