The two patients whom we treated for systemic fungus infections with 5-fluorocytosine, an antifungal agent effective in experimental animal infection with Candida and cryptococci, had a satisfactory clinical response in association with therapy. One patient with Candida sepsis received 5-fluorocytosine for 21 days in a dose ranging from 2 to 4 gm daily. The other patient, with cryptococcal meningitis recurring after amphotericin B treatment, received 5-fluorocytosine in a dose of 2.25 to 9 gm daily for 50 days. There was little evidence of drug toxicity. The new agent deserves controlled clinical evaluation in systemic fungus infections.
Tassel D, Madoff MA. Treatment of Candida Sepsis and Cryptococcus Meningitis With 5-Fluorocytosine: A New Antifungal Agent. JAMA. 1968;206(4):830–832. doi:10.1001/jama.1968.03150040042009
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