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October 21, 1968

Secondary Syphilis With Unusual Clinical and Laboratory Findings

Author Affiliations

From the Department of Medicine, Division of Dermatology, State University of New York, Downstate Medical Center, Brooklyn, NY, and the Division of Dermatology, Kings County Hospital Center. Brooklyn.

JAMA. 1968;206(4):889-891. doi:10.1001/jama.1968.03150040101027

Physical examination of a patient yielded cutaneous findings suggestive of lymphoma or sarcoidosis. A roentgenogram of the chest revealed nodular infiltrates at the bases of both lungs, lending support for the diagnosis of sarcoidosis. On biopsy, skin lesions showed noncaseating granulomata. The correct diagnosis of syphilis was first suspected on the basis of a reactive Venereal Disease Research Laboratory test. Clinically, atypical forms of syphilis may be on the rise because of short-term antibiotic treatment given to patients during the incubation period of the disease.