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October 21, 1968

Use of Ethacrynic Acid in Mannitol-Resistant Oliguric Renal Failure

Author Affiliations

From the Section of Medicine (Drs. Harrison, Tucker, and Anderson) Mayo Clinic and Mayo Foundation, and the sections of medicine (Dr. Auger) and nephrology (Dr. Dayton), Mayo Graduate School of Medicine, University of Minnesota, Rochester.

JAMA. 1968;206(4):891-893. doi:10.1001/jama.1968.03150040103028

Two patients had oliguric acute renal failure in which there was no response to intravenously administered mannitol. In both cases, diuresis resulted after simultaneous administration of mannitol and ethacrynic acid intravenously. Dialysis treatment was unnecessary. The production of a greater volume of urine decreases the tendency toward excess total body water and sodium, and extracellular potassium, and simplifies management. A therapeutic trial with both these drugs may be indicated in the oliguric phase of acute renal failure.