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October 28, 1968

Origins of Physiological Regulations

JAMA. 1968;206(5):1089. doi:10.1001/jama.1968.03150050077030

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This small but weighty book describes the stages of animal development at which physiological regulatory activities appear, and their timing of onset. It is a monograph about the ontogeny of regulation. "Does a regulation spring forth suddenly and fully formed in an embryonic individual? Do regulations of process A and of process B always arise in that order? Do several regulators of process A appear in a particular serial sequence? Are there triggers or prerequisites for some regulations? Can regulations be induced prematurely or delayed?"

Designed for research workers and advanced students, this volume teems with profound observations and suggestions about functional relationships in what is still an uncharted area of physiology. On the one hand, it is a compendium of unusual facts appealing to the comparative physiologist; on the other, it is a treatise on precybernetic principles, reminding the systems analyst that there is yet a world of science