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November 4, 1968

Malignant Transformation in Vitro by Oncogenic Viruses

Author Affiliations

From Harvard Medical School, Massachusetts General Hospital, Boston.

JAMA. 1968;206(6):1258-1262. doi:10.1001/jama.1968.03150060032006

In vitro transformation of animal cells by oncogenic viruses offers a controlled methodology with which to study the malignant process. Quantitative studies of viral transformation reveal that up to 50% of cells can be transformed. Examination of the early biochemical events of viral transformation has disclosed that an induction of synthesis of enzymes operative in deoxyribonucleic acid biosynthetic pathways and a stimulation of host DNA synthesis occurs from 12 to 24 hours after infection of the cells. There is an association of these changes, resulting from a disruption of the regulatory mechanisms of host cell metabolism, with viral transformation. There is