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April 10, 1972

Entero-Vioform for Preventing Travelers' Diarrhea

JAMA. 1972;220(2):273-274. doi:10.1001/jama.1972.03200020081018

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Travelers' diarrhea can be an unpleasant complication of a business or vacation trip abroad. The prospect of succumbing to the "Aztec two-step" or "Delhi belly" causes more anxiety on the part of the prospective traveler than any other health-related aspect of his trip. Because means are available for preventing malaria, smallpox, typhoid, and other more serious threats to the traveler, his natural inclination is to take something he thinks will protect him from diarrhea. The drug most commonly used for this indication is iodochlorhydroxyquin (Entero-Vioform), and over the years it has become the travelers' vade mecum. In this issue of The Journal two letters (p 275) and a case report (p 243) raise the issues of the safety and efficacy of iodochlorhydroxyquin. With the vacation season approaching, physicians should be aware of the controversy concerning iodochlorhydroxyquin and the best methods to prevent travelers' diarrhea.

Diarrhea in travelers occurs most commonly