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To the Editor.—
In a LETTER to the Editor of The Journal for Nov 16, 1957, Kean criticized the advocacy by four consultants (in a query and minor note in The Journal for May 25, 1957) of the use of iodochlorhydroxyquin (Entero-Vioform) and similar preparations for the prophylactic treatment of amebiasis. He stated that evidence to show that iodochlorhydroxyquin is effective in prevention of amebiasis was inadequate and he also suggested potential dangers in using drugs containing iodine as prophylactics. Five years later an EDITORIAL on travelers' diarrhea in The Journal (180:402, 1962) stated that "Entero-Vioform has been used so widely and so long that the lack of scientific evidence for its efficacy has been forgotten."During this 14-year period, no convincing evidence has been put forth that iodochlorhydroxyquin is a useful prophylactic for travelers' diarrhea. Richards, of CIBA Laboratories in England, studying the prophylactic use of iodochlorhydroxyquin as
Wolfe MS, Mishtowt GI. Entero-Vioform in Travelers' Diarrhea. JAMA. 1972;220(2):275–276. doi:10.1001/jama.1972.03200020083020
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