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Article
November 11, 1968

Camptodactyly: A Kindred Study

Author Affiliations

From the Medical Service, Veterans Administration Hospital, Hines, Ill, and the Department of Medicine, University of Illinois Medical Center, Chicago. Mr. Yates is a fourth year medical student at the University of Illinois College of Medicine.

JAMA. 1968;206(7):1565-1567. doi:10.1001/jama.1968.03150070103025
Abstract

Camptodactyly is an autosomal dominant trait occurring in less than 1% of the population. We have studied an involved kindred of 71 persons through seven generations. Penetrance was variable and involvement of the right hand predominated. Prevalence rate decreased with succeeding generations, suggesting "genetic dilution" of a necessary modifier gene. Association with radio-ulnar synostosis was found in two sons of sisters, but orthopedic or biochemical associations were not confirmed, and linkage with peptic ulcer was disestablished.

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