Jaundice, thought to be induced by methimazole, developed in a 54-year-old woman while she was receiving large doses of corticosteroids for malignant exophthalmos. Liver biopsy, taken seven days after the jaundice appeared, showed eosinophilic infiltration in the portal areas which disappeared when use of the drug was discontinued. Four previous cases of hepatitis from methimazole are reviewed and special attention is directed to the occurrence of a "hypersensitivity" drug hepatitis in a patient receiving large doses of corticosteroids.
Charles E. Becker, Phillip Gorden, Jacob Robbins. Hepatitis From Methimazole During Adrenal Steroid Therapy for Malignant Exophthalmos. JAMA. 1968;206(8):1787–1789. doi:10.1001/jama.1968.03150080067019