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December 16, 1968

Furazolidone in Treatment Of Salmonellosis

Author Affiliations

Kasturba Hospital Bombay

JAMA. 1968;206(12):2745. doi:10.1001/jama.1968.03150120079037

To the Editor:—  Based on the in vitro findings of Yurchenco et al1 and Rogers et al2 on the activity of furazolidone on Salmonella typhosa and S paratyphi organisms, and some recent clinical papers on the successful treatment of enteric fevers by furazolidone, I undertook a comparative trial on furazolidone (Furoxone) and chloramphenicol in the treatment of proven cases on enteric fevers. The criterion used for the diagnosis was the detection of Salmonella in clot cultures.I have now a series of 42 cases treated with furazolidone and another series of 57 cases concurrently treated with chloramphenicol.The daily dosage employed was 2 gm of chloramphenicol in four equal doses till defervescence and continued for a further period of ten days on a tapering dose. Furazolidone, 600 mg, was administered in three equal doses till defervescence and continued unaltered for six apyrexial daysIn the furazolidone series, 25