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December 16, 1968

Jakob-Creutzfeldt Disease

JAMA. 1968;206(12):2746-2747. doi:10.1001/jama.1968.03150120080041

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The last few years have seen a renewed interest in the clinical features of Jakob-Creutzfeldt disease, its identity among the presenile dementias, its pathology, and very recently its apparent transmission to chimpanzees.

Dr. Kirschbaum writes with great authority, for his personal contributions date from the very earliest recognition of the condition and remain fundamental to its understanding. They may well outweigh those of Creutzfeldt, in spite of the eponym.

The monograph begins with an excellent brief historical account, followed by a thorough discussion of the clinical manifestations and a clear description of the neuropathology, including electronmicroscopic studies and the suggestion that virological investigations may prove valuable (as, indeed, they have since the book was finished). Over half the volume is devoted to the tabular presentation of 150 cases and detailed descriptions of 17. There is a comprehensive bibliography. The illustrations are carefully chosen and technically good, though reproduced on semimatte