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December 23, 1968

Acute Tendinitis and Arthritis: A Presenting Symptom of Familial Type II Hyperlipoproteinemia

Author Affiliations

From the Laboratory of Molecular Diseases, National Heart Institute, National Institutes of Health, Bethesda, Md.

JAMA. 1968;206(13):2895-2897. doi:10.1001/jama.1968.03150130053018

Achilles tendinitis and tenosynovitis, sometimes accompanied by arthritis, were common presenting symptoms in 14 patients from 9 different kindreds with familial type II hyperlipoproteinemia. Attacks occurred 4 to 12 times per year, lasted two to three days, occurred unilaterally and bilaterally, and recurred over spans of up to 40 years without joint deformity or loss of motion. Appearance of symptoms in the midteens in the majority of patients provides an opportunity for early diagnosis, family screening, and therapy in this inherited disorder associated with accelerated coronary atheromatosis.