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January 5, 1976

Treatment of Kallmann Syndrome

Author Affiliations

Sacramento, Calif

JAMA. 1976;235(1):23-24. doi:10.1001/jama.1976.03260270013014

To the Editor.—  I would like to share with your readers a fairly common case in which the unhappy outcome might have been averted with proper planning.

Report of a Case.—  A 27-year-old man was seen at another hospital for cellulitis. He was a prepubertal male as confirmed by history and physical examination. Laboratory evaluation disclosed low testosterone, follicle-stimulating and luteinizing hormone levels, and semen analysis showed aspermia. The finding of anosmia confirmed the diagnosis of Kallmann syndrome.1 Treatment was started with testosterone enanthate, 200 mg every three weeks.Four months later, the patient moved and was seen at an endocrine clinic for further care. History and results of physical and endocrine evaluations confirmed the diagnosis of Kallmann syndrome. He appeared stable psychosocially and was tolerating his "puberty" without apparent problems. The testosterone therapy was continued at the same dose, but ten days later, he attacked and stabbed two