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January 12, 1976

Diseases of Muscle: A Study in Pathology

Author Affiliations

University of Iowa Hospitals Iowa City

JAMA. 1976;235(2):210. doi:10.1001/jama.1976.03260280058033

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The first edition of Diseases of Muscle, written to fill an unmet need for a comprehensive account of myopathic disease, soon became a widely accepted standard reference work. Only one of the original three authors undertook the ambitious task of revising and updating this text, based on his continued interest and a review of existing literature.

Despite the title, this book encompasses much more than muscle pathology. The initial section provides a concise, readable, well-illustrated review of skeletal muscle embryology, microscopic and ultrastructural anatomy, and histochemical methods used to delineate various fiber types. The next chapter lucidly describes motor end plates and blood vessels. The unit on muscle spindles could have been enriched by electron micrographs to show the detailed, intricate structure of these all-too-long neglected, complicated, and important neuromuscular regulators. Although brief, the section on contractile protein, energy mechanisms, neuromuscular control, and contraction eloquently summarizes the fascinating concepts of