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January 19, 1976

Sudden Infant Death Syndrome

JAMA. 1976;235(3):249. doi:10.1001/jama.1976.03260290011007

To the Editor.—  Smith and Cho (233:861, 1975) reported cytomegalovirus interstitial pneumonitis in a case of sudden infant death syndrome (SIDS) and referred to two other cases from the literature. I can add two more cases (unpublished) from Wayne County, Michigan. Cytomegalovirus is known to cause respiratory tract infections in the first year of life (Proc Soc Exp Biol Med 132:957, 1969). I agree with the authors that some may be missed in SIDS.Virus isolations from postmortem material in SIDS have been unrewarding and inconclusive. During the same period and time when SIDS incidence is at a peak, however, infants hospitalized for respiratory tract infections have yielded a high rate of respiratory pathogens.1 Double virus infections are not uncommon. In infants less than 1 year of age, the respiratory syncytial virus was more frequently isolated, and with lesser frequency, rhinovirus, adenovirus, parainfluenza, enterovirus, and influenza virus. Mycoplasma pneumoniae