It has been said that Candida albicans can be a better clinician than most physicians and may detect systemic abnormalities before they are recognizable at the laboratory level. Chronic mucocutaneous candidiasis developed in a 7-year-old boy long before a diagnosis of marked hypothyroidism (thyroid stimulating hormone, 825μU/ml; T4 test [tetraiodothyronine], 0.3μg/100 ml) could be established. Normalization of the thyroid status by replacement therapy resulted in dramatic improvement of the infection which had previously been resistant to prolonged anticandidal treatment.
Montes LF, Pittman CS, Moore WJ, Taylor CD, Cooper MD. Chronic Mucocutaneous Candidiasis: Influence of Thyroid Status. JAMA. 1972;221(2):156–159. doi:10.1001/jama.1972.03200150022005
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