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July 10, 1972

Chronic Mucocutaneous Candidiasis: Influence of Thyroid Status

Author Affiliations

From the departments of dermatology (Drs. Montes and Moore), endocrinology (Dr. Pittman), and pediatrics, (Dr. Cooper), University of Alabama in Birmingham Medical Center, Birmingham, Ala. Dr. Taylor is in private practice in Columbus, Ga.

JAMA. 1972;221(2):156-159. doi:10.1001/jama.1972.03200150022005

It has been said that Candida albicans can be a better clinician than most physicians and may detect systemic abnormalities before they are recognizable at the laboratory level. Chronic mucocutaneous candidiasis developed in a 7-year-old boy long before a diagnosis of marked hypothyroidism (thyroid stimulating hormone, 825μU/ml; T4 test [tetraiodothyronine], 0.3μg/100 ml) could be established. Normalization of the thyroid status by replacement therapy resulted in dramatic improvement of the infection which had previously been resistant to prolonged anticandidal treatment.